Unable to Connect Hardware Wallet on MyEtherWallet

Restart your computer (Do not be lazy. Restart it FIRST).
Use Google Chrome.
Make sure you don't have any other apps that connect to your Ledger open (e.g. the Ledger Bitcoin Chrome app, Mist, etc.)
Make sure you have browser support turned ON. (This option is on the Ledger Nano S itself in Settings)
Make sure you have contract data turned ON. (This option is also on the Ledger Nano S itself in Settings)
That you are confirming any transactions via your Ledger.
Try a different USB cable